|
|
(A) Genotoxic and non-genotoxic carcinogens
and Molecular Toxicology
Beddowes, E.J., Faux, S.P. and Chipman, J.K. Chloroform, carbon tetrachloride
and glutathione depletion induce secondary genotoxicity in liver cells via
oxidative stress. Toxicology, 187, 101-115, (2003).
Chipman JK , Mally A , Edwards GO.. Disruption of gap junctions in
toxicity and carcinogenicity, Toxicological Sciences, 71, 146-153..2003
Currie RA , Vincent Bombail V, Jason Oliver J, David J. Moore DJ, Fei
Ling Lim FL, Victoria Gwilliam V, Ian Kimber I, Kevin Chipman K,
Jonathan G. Moggs JG and George Orphanides G .Gene ontology mapping as
an unbiased method for identifying molecular pathways and processes
affected by toxicant exposure : application to acute effects caused by
the rodent non-genotoxic carcinogen diethylhexylphthalate. Toxicological
Sciences. 86, 453-469, 2005.
Field JM , Tate, TA, Chipman,JK , Minchin.SD. Identification of
functional regulatory regions of the connexin32 gene promoter, Biochim
Biophys Acta. 2003 Jul 9;1628(1):22-9.
Lee AJ, Hodges N and Chipman JK Modified comet assay as a biomarker of
sodium dichromate-induced oxidative DNA damage: optimisation and
reproducibility. Biomarkers. 9, 103-115, 2004.
Lee AJ, Hodges N and Chipman JK Inter-individual variability in
response to sodium dichromate induced oxidative DNA damage: Role of the
Ser326Cys polymorphism in the DNA-repair protein of 8-oxo
7,8-dihydro-2'-deoxyguanosine DNA glycosylase 1 (OGG1).Cancer
epidemiology biomarkers prevention. 14, 497-505, 2005.
Mally A and
Chipman JK Non-genotoxic carcinogens: early effects on gap junctions,
cell proliferation and apoptosis in the rat.Toxicology, 180, 233-248, (2002)
Hodges NJ, Smart DL, Lee AJ, Lewis NA, Chipman JK Activation of c-jun
N-terminal kinase in A549 lung carcinoma cells by sodium dichromate:
Role of dissociation of apoptosis signal regulating kinase-1 from its
physiological inhibitor thioredoxin. Toxicology 197, 101-112, 2004.
Harper, A., J., Kerr, D.J., Gescher, A. and Chipman, J.K. Antioxidant
effects of isoflavonoids and lignans, and protection against DNA
oxidation. Free Radical Research 31, 149-160, (1999).
Hodges, N.J. and Chipman, J.K. Down-regulation of the DNA-repair
endonuclease 8-oxo-guanine DNA glycosylase 1 (hOGG1) by sodium
dichromate in cultured human A549 lung carcinoma cells. Carcinogenesis,
23, 55-60, (2002).
(B) Environmental Biomarkers/
Eco-toxicogenomics
Franklin, T.M., Lee, J-S., Kohler, A. and Chipman, J.K. Analysis of
mutations in the p53 tumour suppressor gene and Ki- and Ha-raas proto-oncogenes
in hepatic tumours of European flounder (Platichthys flesus).
Marine Env. Res. 50, 251-255 (2000).
Large A.T., Shaw, J.P., Peters, L.D., McIntosh, A.D., Webster, L., Mally,
A. and Chipman, J.K. Different levels of mussel (Mytilus esulis)
DNA strand breaks following chronic field and acute laboratory exposure
to polycyclic aromatic hydrocarbons. Marine Env. Res. 54, 493-497,
(2002).
Large A.T., Shaw, J.P., Peters, L.D., McIntosh, A.D., Webster, L., Mally,
A. and Chipman, J.K. Different levels of mussel (Mytilus esulis)
DNA strand breaks following chronic field and acute laboratory exposure
to polycyclic aromatic hydrocarbons. Marine Env. Res. 54, 493-497,
(2002).
Lee, J-S., Park, E-H., Choe, J. and Chipman, J.K. N-methyl-N-nitrosourea
(MNU) induces papillary thyroid tumours which lack ras gene mutations in
the hermaphroditid fish Rivulus marmoratus. Teratogenesis,
Carcinogenesis and Mutagenesis 20, 1-9 (2000).
Rotchell, J.R. Lee, J-S., Chipman, J.K. and Ostrander, G.K. Structure,
expression and activation of fish ras genes. Aquatic Toxicology, 55,
1-21, (2001).
Williams, T.D., Gensberg, K., Minchin,
S.D. and Chipman, J.K. A DNA expression array to detect toxic stress
response in European flounder (Platichthys flesus). Aquatic
Toxicology.Aquat
Toxicol. 2003 Oct 29;65(2):141-57
Williams, T.D., Lee, J-S., Sheader, D.L. and Chipman, J.K. The
cytochrome P450 1A gene (CYP1A) from European flounder (Platichthys
flesus L.) analysis of regulatory regions and development of a dual
luciferase reporter gene system. Marine Env. Res. 50, 1-6 (2000).
|