Welcome to the Cooper Mass Spectrometry Group

Our research focuses on the development of novel methods for in situ analysis of biomolecules by mass spectrometry.

Thermo Orbitrap Elite Bruker 7T solarix FT-ICR

Liquid extraction surface analysis (LESA) mass spectrometry

We are developing methods for direct sampling of surfaces (dried blood spots, tissue sections, membranes) coupled with high resolution mass spectrometry for targeted and untargeted analysis of proteins and small molecules. For example, we have developed a fast, unambiguous method for diagnosis of haemoglobin variants in newborns. We are currently developing native LESA mass spectrometry.

Cover picture for Journal of the American Society for Mass SpectrometryThe triversa using LESA to analyse a dried blood spot.

FAIMS

High field asymmetric waveform ion mobility spectrometry (FAIMS), also known as differential ion mobility offers advantages for the analysis of biomolecules. In addition to unravelling the underlying mechanisms of FAIMS, we are developing methods to couple FAIMS with LESA mass spectrometry and with proteomics for improved analysis of proteins. We are also developing software for interpretation and visualisation of FAIMS data.

total ion transmission map uFAIMS Rotating total ion tranmission map uFAIMS standard.

Electron mediated dissociation

We are interested in understanding the fundamentals of gas-phase peptide fragmentation, specifically electron capture dissociation, electron transfer dissociation and related approaches, by use of a model peptide approach. We are also developing electron mediated approaches for targeted analysis of protein post-translational modifications.

Andrew Jones model A Andrew Jones model BAndrew Jones model C
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