Publicover Research Group
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- Reproductive Medical Research
- Bone Cell Research
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Our major areas of interest are activation of the human sperm acrosome reaction by physiological agonists, the involvement of Ca2+ channels in this process and the mechanisms of transduction of mechanical and hormonal stimuli in bone cells (osteoblasts, osteocytes and marrow stromal cells). The Research Group uses electrophysiological, ion-imaging and molecular techniques to study transduction of stimuli at the population, single- and sub-cellular level by ion channel activity and second messenger pathways. Current work includes work on mutual recognition in human gametes and transduction of recognition stimuli.

Other recent work has concerned synaptic transmission and its modulation by patterns of synaptic activity (synaptic plasticity) and participation of [Ca2+]i in drug-induced and hypoxic cellular pathology.

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