AntiMicrobial Resistance (AMR) continues to expand and new AMR mitigation approaches are urgently needed that go beyond just prudent antimicrobial use. It is crucial to understand all key drivers of AMR transmission, including human waste-borne AMR disseminated via urban water systems (UWSs). Because most Europeans reside in cities (around 75%), community and hospital antimicrobial use and AMR releases in wastes must impact AMR. However, how use and waste source translates across UWSs is poorly understood. Project DARWIN (Dynamics of Antimicrobial Resistance in the Urban Water Cycle in Europe) is focused on improving this understanding.
My main task, in collaboration with Dr. Kreft, is to undertake the mathematical modeling part of the research outlined previously. In essence, developing mathematical models and Bayesian inference methods to select appropriate models and infer parameters describing the dynamics of antimicrobial resistance genes, plasmids, and their host bacteria in several compartments of three urban water cycles in the UK, Spain and Denmark.

Brief CV

  • Current: Postdoc Research Associate in Antimicrobial Resistance Modelling belonging Project DARWIN (Dynamics of Antimicrobial Resistance in the Urban Water Cycle in Europe)
  • 2013 - 2017: PhD student Centre de Recerca Matematica (Campus Bellaterra), Computational & Mathematical Biology group, Bellaterra, Spain
  • 2008-2012: Research Laboratory Technician, group of Environmental Technology, University of Valladolid, Spain


Roberto de la Cruz, Ruben Perez-Carrasco, Pilar Guerrero, Tomas Alarcon, Karen M Page(2018). Minimum action path theory reveals the details of stochastic transitions out of oscillatory states. Physical review letters 12, 128102

Roberto de la Cruz, Pilar Guerrero, Juan Calvo, Tomás Alarcón(2017). Coarse-graining and hybrid methods for efficient simulation of stochastic multi-scale models of tumour growth. Journal of computational physics 350, 974-991

Roberto de la Cruz, Pilar Guerrero, Fabian Spill, Tomás Alarcón(2016). Stochastic multi-scale models of competition within heterogeneous cellular populations: Simulation methods and mean-field analysis. Journal of Theoretical Biology 407, 161-183

Roberto de la Cruz, Pilar Guerrero, Fabian Spill, Tomás Alarcón(2015). The effects of intrinsic noise on the behaviour of bistable cell regulatory systems under quasi-steady state conditions. The Journal of Chemical Physics 7, 08B610_1

Jose M Abelleira-Pereira, Sara I Pérez-Elvira, Jezabel Sánchez-Oneto, Roberto de la Cruz, Juan R Portela, Enrique Nebot(2015). Enhancement of methane production in mesophilic anaerobic digestion of secondary sewage sludge by advanced thermal hydrolysis pretreatment. Water Research 71, 330-340


DARWIN Project is funded by JPIAMR

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