Professor Helen Cooper

Professor Helen Cooper Expert mass spectrometrist

Helen J. Cooper is Professor of Mass Spectrometry in the School of Biosciences at the University of Birmingham. Her research interests focus on gas-phase ion chemistry of biomolecules and other biologically-relevant species. A particular interest is radical-driven fragmentation. More recently, her interests have focused on ambient surface mass spectrometry and ion mobility spectrometry.

Helen obtained her BSc and PhD in Chemistry from the University of Warwick. After a brief spell in industry, she returned to the University of Warwick before moving to Florida State University in 2000. She returned to the UK, taking up a post at the University of Birmingham, in 2003.

Publications

ORCID logo https://orcid.org/0000-0003-4590-9384

2022

  1. E. Illes-Toth, O. J. Hale, J. W. Hughes, N. Strittmatter, J. Rose, B. Clayton, R. Sargeant, S. Jones, A. Dannhorn, R. J. Goodwin, H.J. Cooper. Mass Spectrometry Detection and Imaging of a Non-Covalent Protein–Drug Complex in Tissue from Orally Dosed Rats. Angew. Chem. Int. Ed. 2022.
  2. O.J. Hale, J. W. Hughes, E.K. Sisley, H.J. Cooper. Native Ambient Mass Spectrometry Enables Analysis of Intact Endogenous Protein Assemblies up to 145 kDa Directly from Tissue. Anal. Chem. 2022, 94, 14, 5608–5614.
  3. Sisley, E. K.; Hale, O. J.; Styles, I. B.; Cooper, H. J. Native Ambient Mass Spectrometry Imaging of Ligand-Bound and Metal-Bound Proteins in Rat Brain. J. Am. Chem. Soc. 2022.
  4. 2021

    1. O.J. Hale, J. W. Hughes and H.J. Cooper. Simultaneous spatial, conformational, and mass analysis of intact proteins and protein assemblies by nano-DESI travelling wave ion mobility mass spectrometry imaging, International Journal of Mass Spectrometry, 2021, 468, 116656.
    2. O.J. Hale and H.J. Cooper. Native Mass Spectrometry Imaging of Proteins and Protein Complexes by Nano-DESI, Analytical Chemistry, 2021.
    3. J. Havlikova, R.C. May, I.B. Styles and H.J. Cooper. Liquid Extraction Surface Analysis Mass Spectrometry of ESKAPE Pathogens. Journal of the American Society for Mass Spectrometry, 2021
    4. 2020

      1. O.J. Hale and H.J. Cooper. Native Mass Spectrometry Imaging and In Situ Top-Down Identification of Intact Proteins Directly from Tissue Journal of the American Society for Mass Spectrometry, 31, 12, 2531–2537.
      2. J. Havlikova, R.C. May, I.B. Styles and H.J. Cooper. Direct identification of bacterial and human proteins from infected wounds in living 3D skin models. Scientific Reports, 10, 11900.
      3. O.J. Hale, E. Illes-Toth, T.H. Mize, and H.J. Cooper. High-Field Asymmetric Waveform Ion Mobility Spectrometry and Native Mass Spectrometry: Analysis of Intact Protein Assemblies and Protein Complexes. Analytical Chemistry, 92, 10, 6811-6816.
      4. E.K. Sisley, J. Ujma, M. Palmer, K. Giles, F.A. Fernandez-Lima, and H.J. Cooper. LESA Cyclic Ion Mobility Mass Spectrometry of Intact Proteins from Thin Tissue Sections. Analytical Chemistry, 92, 9, 6321-6326.
      5. O.J. Hale, E.K. Sisley, R.L. Griffiths, I.B. Styles and H.J. Cooper. Native LESA TWIMS-MSI: spatial, conformational and mass analysis of proteins and protein complexes. Journal of the American Society for Mass Spectrometry, 31, 4, 873-879.
      6. O.J. Hale and H.J. Cooper. In situ mass spectrometry analysis of intact proteins and protein complexes from biological substrates. Biochemical Society Transactions, BST20190793.
      7. R.L. Griffiths, J. Hughes, S.E. Abbatiello, M.W. Belford, I.B. Styles and H.J. Cooper. Comprehensive LESA Mass Spectrometry Imaging of Intact Proteins by Integration of Cylindrical FAIMS. Analytical Chemistry, 2885-2890.
      8. K.I. Kocurek, J. Havlikova, E. Buchan, A. Tanner, R.C. May and H.J. Cooper. Electroporation and Mass Spectrometry: A New Paradigm for In Situ Analysis of Intact Proteins Direct from Living Yeast Colonies. Analytical Chemistry, 2605-2611.

      2019

      1. R.L. Griffiths, A. Konijnenberg, R. Viner and H.J. Cooper. Direct Mass Spectrometry Analysis of Protein Complexes and Intact Proteins up to >70 kDa from Tissue. Analytical Chemistry, 91, 11, 6962-6966.
      2. R.L. Griffiths, K.I. Kocurek and H.J. Cooper. Liquid Extraction Surface Analysis (LESA) High-Field Asymmetric Waveform Ion Mobility Spectrometry (FAIMS) Mass Spectrometry for In Situ Analysis of Intact Proteins. in Ion Mobility-Mass Spectrometry, pp 191-201.
      3. C. Costa, E.M. van Es, P. Sears, J. Bunch, V. Palitsin, H.J. Cooper and M.J. Bailey. Exploring a route to a selective and sensitive portable system for explosive detection-swab spray ionisation coupled to a high-field asymmetric waveform ion mobility mass spectrometry (FAIMS). Forensic Science International: Synergy, 1, 214-220.
      4. E.A. Palmer, H.J. Cooper and W.B. Dunn. Investigation of the 12-Month Stability of Dried Blood and Urine Spots Applying Untargeted UHPLC-MS Metabolomic Assays. Analytical Chemistry, 91, 22, 14306-14313.
      5. A.L. Simmonds, A.F. Lopez-Clavijo, P.J. Winn, D.H. Russell, I.B. Styles and H.J. Cooper. Structural analysis of 14-3-3-ζ-derived phosphopeptides using electron capture dissociation mass spectrometry, travelling wave ion mobility spectrometry, and molecular modeling. The Journal of Physical Chemistry, 461-469.
      6. J. Havlikova, E.C. Randall, R.L. Griffiths, J.G. Swales, R.J.A. Goodwin, J. Bunch, I.B. Styles and H.J. Cooper. Quantitative Imaging of Proteins in Tissue by Stable Isotope Labeled Mimetic Liquid Extraction Surface Analysis Mass Spectrometry. Analytical Chemistry, 14198-14202.
      7. E. Illes-Toth and H.J. Cooper. Probing the Fundamentals of Native Liquid Extraction Surface Analysis Mass Spectrometry of Proteins: Can Proteins Refold during Extraction? Analytical Chemistry, 12246-12254.
      8. K.I. Kocurek, R.C. May and H.J. Cooper. Application of High-Field Asymmetric Waveform Ion Mobility Separation to LESA Mass Spectrometry of Bacteria. Analytical Chemistry, 4755-4761.
      9. E.K. Sisley, E. Illes-Toth and H.J. Cooper. In situ analysis of intact proteins by ion mobility mass spectrometry. Trends in Analytical Chemistry.
      10. J.R.N. Haler, E.K. Sisley, Y.L. Cintron-Diaz, S.N. Meitei, H.J. Cooper and F. Fernandez-Lima. Workflow for fast lipid tissue screening using LESA-FT-ICR-MS. Analytical Methods, 2385-2395.

      2018

      1. C. Cayrou, A.A. Akinduko, E.M. Mirkes, J. Lucidarme, S.A. Clark, L.R. Green, H.J. Cooper, J. Morrissey, R. Borrow and C.D. Bayliss. Clustered intergenic region sequences as predictors of factor H Binding Protein expression patterns and for assessing Neisseria meningitidis strain coverage by meningococcal vaccines. PLoS ONE, 13, 5, e0197186.
      2. A.F. Lopez-Clavijo, R.L. Griffiths, R.J.A. Goodwin and H.J. Cooper. Liquid Extraction Surface Analysis (LESA) Electron-Induced Dissociation and Collision-Induced Dissociation Mass Spectrometry of Small Molecule Drug Compounds. Journal of American Society for Mass Spectrometry, 29, 11, 2218-2226.
      3. R.L. Griffiths, A.L. Simmonds, J. Swales, R. Goodwin and H.J. Cooper. LESA MS imaging of heat preserved and frozen tissue: Benefits of multi-step static FAIMS. Analytical Chemistry, 13306-13314.
      4. C. Rosting, J. Yu and H.J. Cooper. High Field Asymmetric Waveform Ion Mobility Spectrometry in Nontargeted Bottom-up Proteomics of Dried Blood Spots. Journal of Proteome Research, 1997–2004.
      5. K.I. Kocurek, R.L. Griffiths and H.J. Cooper. Ambient ionization mass spectrometry for in situ analysis of intact proteins. Journal of Mass Spectrometry, 565-578.
      6. R.L. Griffiths, K.I. Kocurek and H.J. Cooper. Ambient surface mass spectrometry-ion mobility spectrometry of intact proteins. Current Opinion in Chemical Biology, 67-75.

      2017

      1. R.L. Griffiths, E.K. Sisley, A.F. Lopez-Clavijo, A.L. Simmonds, I.B. Styles and H.J. Cooper. Native mass spectrometry imaging of intact proteins and protein complexes in thin tissue sections. International Journal of Mass Spectrometry, 23-29.
      2. K.I. Kocurek, L. Stones, J. Bunch, R.C. May and H.J. Cooper. Top-Down LESA Mass Spectrometry Protein Analysis of Gram-Positive and Gram-Negative Bacteria. Journal of the American Society for Mass Spectrometry, 1-12.
      3. R.L. Griffiths, E.C. Randall, A.M. Race, J. Bunch and H.J. Cooper. Raster-Mode Continuous-Flow Liquid Microjunction Mass Spectrometry Imaging of Proteins in Thin Tissue Sections. Analytical Chemistry, 5683-5687.
      4. T. Powell, S. Bowra and H.J. Cooper. Subcritical water hydrolysis of peptides: amino acid side-chain modifications. Journal of the American Society for Mass Spectrometry, 1-12.

      2016

      1. VA Mikhailov, R.L. Griffiths and H.J. Cooper. Liquid Extraction Surface Analysis for Native Mass Spectrometry: Protein Complexes and Ligand Binding. International Journal of Mass Spectrometry, 43-50.
      2. E.C. Randall, A.M. Race, H.J. Cooper and J. Bunch. MALDI imaging of LESA sampled tissue. Analytical Chemistry, 8433-8440.
      3. R.L. Griffiths, A.J. Creese, A.M. Race, J. Bunch and H.J. Cooper. LESA FAIMS mass spectrometry for the spatial profiling of proteins from tissue. Analytical Chemistry, 6758-6766.
      4. T. Powell, S. Bowra and H.J. Cooper. Subcritical Water Processing of Proteins: An Alternative to Enzymatic Digestion? Analytical Chemistry, 6425-6432.
      5. H.J. Cooper. To What Extent is FAIMS Beneficial in the Analysis of Proteins? Journal of the American Mass Spectrometry Society, 566-577.
      6. H. Zhao, A.J. Creese and H.J. Cooper. Online LC-FAIMS-MS/MS for the Analysis of Phosphorylation in Proteins. Methods in Molecular Biology, 241-250.
      7. R.L. Griffiths and H.J. Cooper. Direct Tissue Profiling of Protein Complexes: Toward Native Mass Spectrometry Imaging. Analytical Chemistry, 606-609.

      2015

      1. H. Zhao, D.L. Cunningham, A.J. Creese, J.K. Heath and H.J. Cooper. FAIMS and Phosphoproteomics of Fibroblast Growth Factor Signaling: Enhanced Identification of Multiply Phosphorylated Peptides. Journal of Proteome Research, 5077-5087.
      2. P. Barran, H.J. Cooper and C. Eyers. Protein Structure. Proteomics, 2731-2732.
      3. A.F. Lopez-Clavijo, C.A. Duque-Daza, A.J. Creese and H.J. Cooper. Electron capture dissociation mass spectrometry of phosphopeptides: Arginine and phosphoserine. International Journal of Mass Spectrometry, 63-70.
      4. R.L. Griffiths, A. Dexter, A.J. Creese and H.J. Cooper. Liquid extraction surface analysis field asymmetric waveform ion mobility spectrometry mass spectrometry for the analysis of dried blood spots. Analyst, 6879-6885.
      5. J. Sarsby, R.L. Griffiths, A.M. Race, J. Bunch, E.C. Randall, A.J. Creese and H.J. Cooper. Liquid extraction surface analysis mass spectrometry coupled with field asymmetric waveform ion mobility spectrometry for analysis of intact proteins from biological substrates. Analytical Chemistry, 6794-6800.
      6. G.N. Ulasi, A.J. Creese, S. Xui Hui, C.W. Penn and H.J. Cooper. Comprehensive mapping of O-glycosylation in flagellin from Campylobacter jejuni 11168: A multi-enzyme differential ion mobility mass spectrometry approach. Proteomics, 2733-2745.
      7. D. Kim, P.J. Pai, A.J. Creese, A.W. Jones, D.H. Russell and H.J. Cooper. Probing the Electron Capture Dissociation Mass Spectrometry of Phosphopeptides with Traveling Wave Ion Mobility Spectrometry and Molecular Dynamics Simulations. Journal of the American Society for Mass Spectrometry, 1004-1013.
      8. N.J. Martin, R.L. Griffiths, R.L. Edwardsand H.J. Cooper. Native Liquid Extraction Surface Analysis Mass Spectrometry: Analysis of Noncovalent Protein Complexes Directly from Dried Substrates. Journal of the American Society for Mass Spectrometry, 1152-1158.
      9. S. He, H. Chen, Z. Zhu, D.G. Ward, H.J. Cooper, M.R. Viant, J.K. Heath and X. Yao. Robust twin boosting for feature selection from high-dimensional omics data with label noise. Information Sciences, 1-18.

      2014

      1. J. Sarsby, N.J. Martin, P.F. Lalor, J. Bunch and H.J. Cooper. Top-Down and Bottom-Up Identification of Proteins by Liquid Extraction Surface Analysis Mass Spectrometry of Healthy and Diseased Human Liver Tissue. Journal of The American Society for Mass Spectrometry, 1953-1961.
      2. E.C. Randall, J. Bunch and H.J. Cooper. Direct analysis of intact proteins from Escherichia coli colonies by liquid extraction surface analysis mass spectrometry. Analytical Chemistry, 10504-10510.
      3. N.J. Martin and H.J. Cooper. Challenges and opportunities in mass spectrometric analysis of proteins from dried blood spots. Expert Review of Proteomics, 1-11.
      4. R.L. Edwards, P. Griffiths, J. Bunch and H.J. Cooper. Compound heterozygotes and beta-thalassemia: Top-down mass spectrometry for detection of hemoglobinopathies. Proteomics, 1232-1238.
      5. M.R. Berwick, D.J. Lewis, A.W. Jones, R.A. Parslow, T.R. Dafforn, H.J. Cooper, J. Wilkie, Z. Pikramenou, M.M. Britton and A.F.A. Peacock. De Novo Design of Ln (III) Coiled Coils for Imaging Applications. Journal of the American Chemical Society, 1166-1169.
      6. J.M.D. Kalapothakis, Y. Berezovskaya, C.G. Zampronio, P.A. Faull, P.E. Barran and H.J. Cooper. Unusual ECD fragmentation attributed to gas-phase helix formation in a conformationally dynamic peptide. Chemical Communications, 198-200.

      2013

      1. R.L. Edwards, N.J. Martin and H.J. Cooper. Hemoglobin variant analysis of whole blood and dried blood spots by MS. Bioanalysis, 2043-2052.
      2. M.A. Kaczorowska and H.J. Cooper. Electron Capture Dissociation and Collision Induced Dissociation of S-Dipalmitoylated Peptides. Journal of The American Society for Mass Spectrometry, 1224-1227.
      3. A.J. Creese, J. Smart and H.J. Cooper. Large-scale analysis of peptide sequence variants: The case for high field asymmetric waveform ion mobility spectrometry. Analytical Chemistry, Editor's highlight, 4836-4843.
      4. N.J. Martin, J. Bunch and H.J. Cooper. Dried blood spot proteomics: Surface extraction of endogenous proteins coupled with automated sample preparation and mass spectrometry analysis. Journal of The American Society for Mass Spectrometry, 1242-1249.
      5. A.J. Creese, N.J. Shimwell, K.P.B. Larkins, J.K. Heath and H.J. Cooper. Probing the Complementarity of FAIMS and Strong Cation Exchange Chromatography in Shotgun Proteomics. Journal of The American Society for Mass Spectrometry, 431-443.

      2012

      1. A.W. Jones, P.J. Winn and H.J. Cooper. The Radical Ion Chemistry of S-Nitrosylated Peptides. Journal of The American Society for Mass Spectrometry, 2063-2074.
      2. R.L. Edwards, P. Griffiths, J. Bunch and HJ Cooper. Top-Down Proteomics and Direct Surface Sampling of Neonatal Dried Blood Spots: Diagnosis of Unknown Hemoglobin Variants. Journal of The American Society for Mass Spectrometry, 1-10.
      3. S. He, H.J. Cooper, D.G. Ward, X. Yao and J.K. Heath. Analysis of premalignant pancreatic cancer mass spectrometry data for biomarker selection using a group search optimizer. Transactions of the Institute of Measurement and Control, 668-676.
      4. C. Singh, C.G. Zampronio, A.J. Creese and H.J. Cooper. Higher energy collision dissociation (HCD) product ion-triggered electron transfer dissociation (ETD) mass spectrometry for the analysis of N-linked glycoproteins. Journal of Proteome Research, 4517-4525.
      5. A.J. Creese and H.J. Cooper. Separation and identification of isomeric glycopeptides by high field asymmetric waveform ion mobility spectrometry. Analytical Chemistry, 2597-2601.

      2011

      1. S. Bennett, M. Grant, A.J. Creese, F. Mangialasche, R. Cecchetti, H.J. Cooper, P. Mecocci and S. Aldred. Plasma Levels of Complement 4a Protein are Increased in Alzheimer's Disease. Alzheimer Disease and Associated Disorders, 329-334.
      2. A.A. Shvartsburg, A.J. Creese, R.D. Smith and H.J. Cooper. Separation of a Set of Peptide Sequence Isomers Using Differential Ion Mobility Spectrometry. Analytical Chemistry, 6918-6923.
      3. J. Hothersall, A.C. Murphy, Z. Iqbal, G. Campbell, E.R. Stephens, J. Wu, H.J. Cooper, S. Atkinson, P. Williams, J. Crosby, C.L. Willis, R.J. Cox, T.J. Simpson and C.M. Thomas. Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production. Applied Microbiology and Biotechnology, 1017-1026.
      4. R.L. Edwards, A.J. Creese, M. Baumert, P. Griffiths, J. Bunch and H.J. Cooper. Hemoglobin variant analysis via direct surface sampling of dried blood spots coupled with high-resolution mass spectrometry. Analytical Chemistry, 2265-2270.
      5. C.G. Zampronio, G. Blackwell, C.W. Penn and H.J. Cooper. Novel Glycosylation Sites Localized in Campylobacter jejuni Flagellin FlaA by Liquid Chromatography Electron Capture Dissociation Tandem Mass Spectrometry. Journal of Proteome Research, 1238-1245.
      6. S. Dean, M. Cox, J. Heptinstall, D.J. Walton, V.A. Mikhailov, H.J. Cooper, M. Gómez-Mingot and J. Iniesta. Nitration of lysozyme by ultrasonic waves; demonstration by immunochemistry and mass spectrometry. Ultrasonics Sonochemistry, 334-344.
      7. A.W. Jones and H.J. Cooper. Dissociation techniques in mass spectrometry-based proteomics. Analyst, 3419-3429.
      8. A.J. Creese, M.M. Grant, I.L.C. Chapple and H.J. Cooper. On-line liquid chromatography neutral loss-triggered electron transfer dissociation mass spectrometry for the targeted analysis of citrullinated peptides. Analytical Methods, 259-266.
      9. M.A. Kaczorowska and H.J. Cooper. Electron induced dissociation (EID) tandem mass spectrometry of octaethylporphyrin and its iron (iii) complex. Chemical Communications, 418-420.

      2010

      1. A.A. Shvartsburg, A.J. Creese, R.D. Smith and H.J. Cooper. Separation of peptide isomers with variant modified sites by high-resolution differential ion mobility spectrometry. Analytical Chemistry, 8327-8334.
      2. M.M. Grant, A.J. Creese, G. Barr, M.R. Ling, A.E. Scott, J.B. Matthews, H.R. Griffiths, H.J. Cooper and I.L.C. Chapple. Proteomic analysis of a noninvasive human model of acute inflammation and its resolution: the twenty-one day gingivitis model. Journal of Proteome Research, 4732-4744.
      3. V.A. Mikhailov, J. Iniesta, H.J. Cooper. Top-down mass analysis of protein tyrosine nitration: Comparison of electron capture dissociation with “slow-heating” tandem mass spectrometry methods. Analytical Chemistry, 7283-7292.
      4. S. Portugal, H.J. Cooper, C.G. Zampronio, L. Wallace and P. Cassey. Can museum egg specimens be used for proteomic analyses? Proteome Science, 40-44.
      5. M.A. Kaczorowska and H.J. Cooper. Electron induced dissociation: A mass spectrometry technique for the structural analysis of trinuclear oxo-centred carboxylate-bridged iron complexes. Journal of The American Society for Mass Spectrometry, 1398-1403.
      6. J. Iniesta, M.D. Esclapez-Vicente, J. Heptinstall, D.J. Walton, I.R. Peterson, V.A. Mikhailov and H.J. Cooper. Retention of enzyme activity with a boron-doped diamond electrode in the electro-oxidative nitration of lysozyme. Enzyme and Microbial Technology, 472-478.
      7. D.L. Cunningham, S.M.M. Sweet, H.J. Cooper and J.K. Heath. Differential phosphoproteomics of fibroblast growth factor signaling: identification of Src family kinase-mediated phosphorylation events. Journal of Proteome Research, 2317-2328.
      8. M.A. Kaczorowska, A.C.G. Hotze, M.J. Hannon and H.J. Cooper. Electron capture dissociation mass spectrometry of metallo-supramolecular complexes. Journal of The American Society for Mass Spectrometry, 300-309.
      9. A.W. Jones, V.A. Mikhailov, J. Iniesta and H.J. Cooper. Electron capture dissociation mass spectrometry of tyrosine nitrated peptides. Journal of The American Society for Mass Spectrometry, 268-277.
      10. A.W. Jones and H.J. Cooper. Probing the mechanisms of electron capture dissociation mass spectrometry with nitrated peptides. Physical Chemistry Chemical Physics, 13394-13399.

      2009

      1. M.A. Kaczorowska and H.J. Cooper. Characterization of polyphosphoesters by fourier transform ion cyclotron resonance mass spectrometry. Journal of The American Society for Mass Spectrometry, 2238-2247.
      2. S.M.M. Sweet, A.W. Jones, D.L. Cunningham, J.K. Heath, A.J. Creese and H.J. Cooper. Database search strategies for proteomic data sets generated by electron capture dissociation mass spectrometry. Journal of Proteome Research, 5475-5484.
      3. J.P. Williams, A.J. Creese, D.R. Roper, B.N. Green and H.J. Cooper. Hot electron capture dissociation distinguishes leucine from isoleucine in a novel hemoglobin variant, Hb Askew, Β54 (D5) Val→Ile. Journal of The American Society for Mass Spectrometry, 1707-1713.
      4. Y. Xuan, A.J. Creese, J.A. Horner and H.J. Cooper. High field asymmetric waveform ion mobility spectrometry (FAIMS) coupled with high resolution electron transfer dissociation mass spectrometry for the analysis of isobaric phosphopeptides. Rapid Communications in Mass Spectrometry, 1963-1969.
      5. V.A. Mikhailov and H.J. Cooper. Activated ion electron capture dissociation (AI ECD) of proteins: Synchronization of infrared and electron irradiation with ion magnetron motion. Journal of The American Society for Mass Spectrometry, 763-771.
      6. S.M.M. Sweet, C.M. Bailey, D.L. Cunningham, J.K. Heath and H.J. Cooper. Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. Molecular & Cellular Proteomics, 904-912.
      7. M.A. Kaczorowska and H.J. Cooper. Electron capture dissociation and collision-induced dissociation of metal ion (Ag+, Cu2+, Zn2+, Fe2+, and Fe3+) complexes of polyamidoamine (PAMAM) dendrimers. Journal of The American Society for Mass Spectrometry, 674-681.
      8. H.J. Cooper. Fourier transform ion cyclotron resonance mass spectrometry in the analysis of peptides and proteins. Pages 121-154.
      9. S.M.M. Sweet and H.J. Cooper. On-line liquid chromatography electron capture dissociation for the characterization of phosphorylation sites in proteins. Methods in Molecular Biology, 191-199.
      10. C.M. Bailey, S.M.M. Sweet, D.L. Cunningham, M. Zeller, J.K. Heath and H.J. Cooper. SLoMo: automated site localization of modifications from ETD/ECD mass spectra. Journal of Proteome Research, 1965-1971.

      2008

      1. A.J. Creese and H.J. Cooper. The effect of phosphorylation on the electron capture dissociation of peptide ions. Journal of The American Society for Mass Spectrometry, 1263-1274.
      2. S.M.M. Sweet, F.K. Mardakheh, K.J.P. Ryan, A.J. Langton, J.K. Heath and H.J. Cooper. Targeted online liquid chromatography electron capture dissociation mass spectrometry for the localization of sites of in vivo phosphorylation in human Sprouty2. Analytical Chemistry, 6650-6657.
      3. J. Iniesta, H.J. Cooper, A.G. Marshall, J. Heptinstall, D.J. Walton and I.R. Peterson. Specific electrochemical iodination of horse heart myoglobin at tyrosine 103 as determined by Fourier transform ion cyclotron resonance mass spectrometry. Archives of Biochemistry and Biophysics, 1-7.
      4. M.A. Kaczorowska and H.J. Cooper. Electron capture dissociation, electron detachment dissociation and collision-induced dissociation of polyamidoamine (PAMAM) dendrimer ions with amino, amidoethanol and sodium carboxylate surface groups. Journal of The American Society for Mass Spectrometry, 1312-1319.

      2007

      1. A. Vecchione, H.J. Cooper, K.J. Trim, S. Akbarzadeh, J.K. Heath and L.M. Wheldon. Protein partners in the life history of activated fibroblast growth factor receptors. Proteomics, 4565-4578.
      2. A.D. Southam, T.G. Payne, H.J. Cooper, T.N. Arvanitis and M.R. Viant. Electron capture dissociation in the analysis of protein phosphorylatioDynamic range and mass accuracy of wide-scan direct infusion nanoelectrospray Fourier transform ion cyclotron resonance mass spectrometry-based metabolomics increased by the spectral stitching method. Analytical Chemistry, 4595-4602.
      3. A.J. Creese and H.J. Cooper. Liquid chromatography electron capture dissociation tandem mass spectrometry (LC-ECD-MS/MS) versus liquid chromatography collision-induced dissociation tandem mass spectrometry (LC-CID-MS/MS) for the identification of proteins. Journal of The American Society for Mass Spectrometry, 891-897.
      4. S.M.M. Sweet and H.J. Cooper. Electron capture dissociation in the analysis of protein phosphorylation. Expert Reviews of Proteomics, 149-159.

      2006

      1. S.M.M. Sweet, A.J. Creese and H.J. Cooper. Strategy for the identification of sites of phosphorylation in proteins: neutral loss triggered electron capture dissociation. Analytical Chemistry, 7563-7569.
      2. D. Matters, H.J. Cooper, L. McDonnell, J. Iniesta, J. Heptinstall, P. Derrick, D. Walton and I. Peterson. Mass spectrometry in demonstrating the site-specific nitration of hen egg white lysozyme by an improved electrochemical method. Analytical Biochemistry, 171-181.

      2005

      1. H.J. Cooper. Investigation of the Presence of b Ions in Electron Capture Dissociation Mass Spectra. Journal of The American Society for Mass Spectrometry, 1932-1940.
      2. H.J. Cooper, S. Akbarzadeh, J.K. Heath and M. Zeller. Data-dependent electron capture dissociation FT-ICR mass spectrometry for proteomic analyses. Journal of Proteome Research, 1538-1544.
      3. G.D. Stentiford, M.R. Viant, D.G. Ward, P.J. Johnson, A. Martin, W. Wenbin, H.J. Cooper, B.P. Lyons and S.W. Feist. Liver tumors in wild flatfish: a histopathological, proteomic, and metabolomic study. Omics: A Journal of Integrative Biology, 281-299.
      4. H.J. Cooper, M.H. Tatham, E. Jaffray, J.K. Heath, T.K.T. Lam, A.G. Marshall and R.T. Hay. Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for the Analysis of Small Ubiquitin-like Modifier (SUMO) Modification: Identification of Lysines in RanBP2 and SUMO Targeted for Modification during the E3 AutoSUMOylation Reaction. Analytical Chemistry, 6310-6319.
      5. M.B. Renfrow, H.J. Cooper, M. Tomana, R. Kulhavy, Y. Hiki, K. Toma, M.R. Emmett, J. Mestecky, A.G. Marshall and J. Novak. Determination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation Fourier transform-ion cyclotron resonance mass spectrometry. Journal of Biological Chemistry, 19136-19145.
      6. T.J. Manning, M. Land, E. Rhodes, J. Rudloe, D. Phillips, T.K.T. Lam, J. Purcell, H.J. Cooper, M.R. Emmett and A.G. Marshall. Identifying bryostatins and potential precursors from the bryozoan Bugula neritina. Natural Product Research, 467-491.
      7. H.J. Cooper, K. Håkansson and A.G. Marshall. The role of electron capture dissociation in biomolecular analysis. Mass Spectrometry Reviews, 201-222.

      2004

      1. H.J. Cooper, J.K. Heath, E. Jaffray, R.T. Hay, T.K.T. Lam and A.G. Marshall. Identification of sites of ubiquitination in proteins: a fourier transform ion cyclotron resonance mass spectrometry approach. Analytical Chemistry, 6982-6988.
      2. H.J. Cooper, R.R. Hudgins and A.G. Marshall. Electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry of cyclodepsipeptides, branched peptides and εpeptides. International Journal of Mass Spectrometry, 23-25.

      2003

      1. M. Schäfer, C. Schmuck, M. Heil, H.J. Cooper, C.L. Hendrickson, M.J. Chalmers and A.G. Marshall. Determination of the gas-phase activation energy for the unimolecular dissociation of a non-covalent complex by infrared multiphoton dissociation tandem Fourier transform ion cyclotron resonance mass spectrometry. Journal of the American Society for Mass Spectrometry, 1282-1289.
      2. H.J. Cooper, K. Håkansson, A.G. Marshall, R.R. Hudgins, K.F. Haselmann, F. Kjeldsen, B.A. Budnik, N.C. Polfer and R.A. Zubarev. The diagnostic value of amino acid side-chain losses in electron capture dissociation of polypeptides. European Journal of Mass Spectrometry, 221-222.
      3. H.J. Cooper, R.R. Hudgins, K. Håkansson and A.G. Marshall. Secondary fragmentation of linear peptides in electron capture dissociation. International Journal of Mass Spectrometry, 723-728.
      4. K. Håkansson, H.J. Cooper, R.R. Hudgins and C.L. Nilsson. High resolution tandem mass spectrometry for structural biochemistry. Current Organic Chemistry, 1503-1525.
      5. H.J. Cooper, M.A. Case, G.L. McLendon and A.G. Marshall. Electrospray ionization Fourier transform ion cyclotron resonance mass spectrometric analysis of metal-ion selected dynamic protein libraries. Journal of the American Chemical Society, 5331-5339.

      2002

      1. M. Nousiainen, H.J. Cooper, D. Fati, A. Hoxha, H.R. Trayer, D.G. Ward, P. Vainiotialo, P.J. Derrick and I.P. Trayer. Calcium and Peptide Binding to Folded and Unfolded Conformations of Cardiac Troponin C. Electrospray Ionization and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. European Journal of Mass Spectrometry, 471-481.
      2. H.J. Cooper, C.L. Hendrickson, R.J. Cross, M. Saunders and A.G. Marshall. Direct detection and quantitation of He@C60 by ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry. Journal of the American Society for Mass Spectrometry, 1349-1355.
      3. A.P.H.J. Schenning, A.F.M. Kilbinger, M. Cavallini, H.J. Cooper, P.J. Derrick, W.J. Feast, R. Lazzaroni, P. Leclère, L.A. McDonnell, E.W. Meijer and S.C.J. Meskers. Supramolecular organization of α,α’-disubstituted sexithiophenes. Journal of the American Chemical Society, 1269-1275.
      4. C.L. Nilsson, H.J. Cooper, K. Håkansson, A.G. Marshall, Y. Östberg, M. Lavrinovicha and S. Bergström. Characterization of the P13 membrane protein of Borrelia burgdorferi by mass spectrometry. Journal of the American Society for Mass Spectrometry, 295-299.
      5. H.J. Cooper, R.R. Hudgins, K. Håkansson and A.G. Marshall. Characterization of amino acid side chain losses in electron capture dissociation. Journal of the American Society for Mass Spectrometry, 241-249.

      2001

      1. H.J. Cooper and A.G. Marshall. Electrospray ionization Fourier-transform mass spectrometric analysis of wine. Journal of Agricultural and Food Chemistry, 5710-5718.
      2. C.A. Hughey, H.J. Cooper, R.P. Rodgers, A.G. Marshall, W.K. Robbins and K. Qian. Resolution and identification of elemental compositions for more than 3000 crude acids in heavy petroleum by negative-ion microelectrospray high-field Fourier transform ion cyclotron resonance mass spectrometry. Energy and Fuels, 1505-1511.
      3. K. Håkansson, H.J. Cooper, M.R. Emmett, C.E. Costello, A.G. Marshall and C.L. Nilsson. Electron capture dissociation and infrared multiphoton dissociation MS/MS of an N-glycosylated tryptic peptide to yield complementary sequence information. Analytical Chemistry, 4530-4536.
      4. G. Kendall, H.J. Cooper, J. Heptinstall, P.J. Derrick, D.J. Walton and I.R. Peterson. Specific electrochemical nitration of horse heart myoglobin. Archives of Biochemistry and Biophysics, 169-179.

      2000

      1. M. Palmblad, K. Håkansson, P. Håkansson, X.D. Feng, H.J. Cooper, A.E. Giannakopulos, P.S. Green and P.J. Derrick. A 9.4 T Fourier transform ion cyclotron resonance mass spectrometer: description and performance. European Mass Spectrometry, 267-275.
      2. G. Notarianni, N. Gusev, D. Lafitte, T.J. Hill, H.J. Cooper, P.J. Derrick and S.B. Marston. A novel Ca2+ binding protein associated with caldesmon in Ca2+-regulated smooth muscle thin filaments: evidence for a structurally altered form of calmodulin. Journal of Muscle Research and Cell Motility, 537-549.
      3. T.J. Hill, D. Lafitte, J.I. Wallace, H.J. Cooper, P.O. Tsvetkov and P.J. Derrick. Calmodulin-peptide interactions: Apocalmodulin binding to the myosin light chain kinase target-site. Biochemistry, 7284-7290.
      4. A.F.M. Kilbinger, H.J. Cooper, L.A. McDonnell, W.J. Feast and P.J. Derrick. Mass spectrometric evidence for aggregation of a substituted sexithiophene. Chemical Communications, 383-384.
      5. X.D. Feng, N. Clipston, T. Brown, H.J. Cooper, U. Reuther, A. Hirsch, P.J. Derrick and T. Drewello. Generation and detection of [C59N]+ by laser desorption/ionisation high-field Fourier transform ion cyclotron resonance mass spectrometry. Rapid Communications in Mass Spectrometry, 368-370.

      1996

      1. H.J. Cooper and P.J. Derrick. Energy Shifts in Collisional Activation. Mass Spectrometry in the Biomolecular Sciences, 201-259.

      1995

      1. J.A. Mosely, H.J. Cooper, R.T. Gallagher and P.J. Derrick. Target capture of argon by fullerene radical cations in high-energy collisions. European Mass Spectrometry, 501-502.
      2. H.J. Cooper, R.T. Gallagher, P.F. Greenwood, T. Vulpius and P.J. Derrick. Evidence for the formation of transient CH4C60+ following high-energy collisions between C60+· radical cations and methane. Journal of the Chemical Society, Chemical Communications, 1459-1460.

      1993

      1. H.J. Cooper, P.J. Derrick, H.D.B. Jenkins and E. Uggerud. Theory of collisional activation of macromolecules-comment. The Journal of Physical Chemistry, 5443-5444.